The Binding of Isaac

The official Binding of Isaac multiplayer card game, about sacrifice, betrayal and hoarding. 2-4 players take turns playing loot cards and using items to kill monsters that yield more items, loot, and sometimes souls. The first player to end their turn with 4 souls is the winner. Cooperation, barter, and betrayal is encouraged. This is the Second Edition of The Binding of Isaac: Four Souls. All cards have been updated with enhanced backgrounds and updated wording for clarity.