In the Footsteps of Marie Curie is a game featuring resource management and transformation mechanics with a card river and contracts. Resources distribution (Pitchblende, Uranium, and Radium) is done through a cube tower, and the retention or overproduction of these brings a set of surprises each turn. Players progress on a central board through Marie Curie's life timeline. The game ends when players reach the end of this timeline.
Players take turns, starting with the first player and then proceeding clockwise until the Timeline marker reaches the last space of the timeline. At that point, players complete the current round up to the last player and the game ends. The player with the most Victory Points (VP) wins the game.